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Apoer2. Select ApoER2 antibodies from monoclonal antibodies listed below. - Long-term security of supply. Synthetic peptide within Human ApoER2 aa 800-900 conjugated to keyhole limpet haemocyanin. Little is known about the function of the apoE-ApoER2 tandem outside of the central nervous system.
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The ApoE receptors Apoer2 and Vldlr and their primary ligand Reelin are vital for brain development and important for modulation of synaptic plasticity. Function i Keywords i. It is known that both ApoER2 and p75NTRare processed by metalloproteinases followed by regulated intramembrane proteolysis. Names Taxonomy i. This product is a recombinant monoclonal antibody which offers several advantages including. View detailed ApoER2 antibody specifications by linking to the specific product blocks.
Thus Apoer2 appears to be the dominant Reelin receptor at least in the forebrain.
We now report that in endothelial cells apoE3 binding to ApoER2 stimulates endothelial NO synthase eNOS and endothelial cell migration and it also attenuates monocyte-endothelial cell adhesion. ApoER2 and the neurotrophin receptors Trk and p75NTRare expressed in the CNS and regulate key functional aspects of neurons including development survival and neuronal function. For more information see here. Apolipoprotein E receptor 2 ApoER2 and VLDL receptor belong to the low density lipoprotein receptor family and bind apolipoprotein E. ApoER2 expression was highest during postnatal inner retinal synaptic development and was considerably lower in the mature retina. These receptors interact with the clathrin machinery to mediate endocytosis of macromolecules but also interact with other adapter proteins to perform as signal transduction receptors.
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ApoER2 expression was highest during postnatal inner retinal synaptic development and was considerably lower in the mature retina. Disruption of these pathways is implicated in various neurodevelopmental disorders and ApoE4 appears to mediate some of its effects in AD pathogenesis by interfering with Reelin signaling in the adult brain. Synthetic peptide within Human ApoER2 aa 800-900 conjugated to keyhole limpet haemocyanin. These receptors interact with the clathrin machinery to mediate endocytosis of macromolecules but also interact with other adapter proteins to perform as signal transduction receptors. TrkA activation by nerve growth factor NGF.
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If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs please contact our Scientific Support team to discuss your requirements. Synthetic peptide within Human ApoER2 aa 800-900 conjugated to keyhole limpet haemocyanin. Function i Keywords i. For more information see here. Santa Cruz Biotechnology Inc.
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Function i Keywords i. Synthetic peptide within Human ApoER2 aa 800-900 conjugated to keyhole limpet haemocyanin. ApoER2 flfl mice were created by insertion of loxP sites flanking exons 1 and 2 supplemental Figure 1A available on the Blood Web site. Thus Apoer2 appears to be the dominant Reelin receptor at least in the forebrain. Select appropriate ApoER2 antibodies for your research by isotype epitope applications and species reactivity.
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For more information see here. Disruption of these pathways is implicated in various neurodevelopmental disorders and ApoE4 appears to mediate some of its effects in AD pathogenesis by interfering with Reelin signaling in the adult brain. ApoER2 flfl mice were created by insertion of loxP sites flanking exons 1 and 2 supplemental Figure 1A available on the Blood Web site. Little is known about the function of the apoE-ApoER2 tandem outside of the central nervous system. ApoER2 Polyclonal Antibody Formalin-fixed and paraffin embedded chicken lung labeled with Anti ApoER2 Polyclonal Antibody Unconjugated bs-6651R at 1200 followed by conjugation to the secondary antibody and DAB staining.
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Thus Apoer2 appears to be the dominant Reelin receptor at least in the forebrain. These receptors interact with the clathrin machinery to mediate endocytosis of macromolecules but also interact with other adapter proteins to perform as signal transduction receptors. - High batch-to-batch consistency and reproducibility. - Long-term security of supply. The exact immunogen sequence used to generate this antibody is proprietary information.
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