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Cathepsin S Inhibitor. To date several classes of Cat S inhibitors have been reported many of which form. Cathepsin S inhibition has been considered a potential therapeutic approach for atherosclerosis. Furthermore BI-1124 has a superior PK profile and showed dose-dependent inhibition of the ovalbumin induced IL-2 secretion in a T cell receptor transgenic DO11 mouse model with an IC 50 of 03 mgkg. A polyclonal antibody raised in Rabbit that recognizes and binds to Human Cathepsin S.
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Cathepsin S As an Inhibitor of Cardiovascular Inflammation and Calcification in Chronic Kidney Disease. The inhibition of Cathepsin S is expected to result in immunosuppression which makes this enzyme an attractive target to potentially treat autoimmune and inflammatory diseases. - Find MSDS or SDS a COA data sheets and more information. MCE has not independently confirmed the accuracy of these methods. Other researchers have also inquired about various cathepsin S inhibitors as treatment for cardiovascular disorders. Cathepsin S Cat S plays an important role in many pathological conditions including abdominal aortic aneurysm AAA.
The inhibition of Cathepsin S is expected to result in immunosuppression which makes this enzyme an attractive target to potentially treat autoimmune and inflammatory diseases.
The inhibition of Cathepsin S is expected to result in immunosuppression which makes this enzyme an attractive target to potentially treat autoimmune and inflammatory diseases. Cathepsin S inhibitors prevent presentation of antigen from different MHC-II haplotypes 84 and they may be considered as therapeutic targets to reduce the inflammatory response in atherosclerosis. Inhibition of Cat S may provide a new treatment for AAA. Cathepsin S inhibitor is a novel Cathepsin S inhibitor. Sena BF 1 Figueiredo JL 2 Aikawa E 3. BI-1915 is a highly potent inhibitor of Cathepsin S IC 50 17 nM for in vitro use that effectively blocks the specific ovalbumin induced IL-2 secretion in T-cells with an EC 50 value of 28 nM and shows excellent selectivity against related cathepsins with IC 50 values of 10 µM.
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Exhibits 410-fold greater selectivity over cathepsin B Ki 76 nM. Ahmad and Siddiqi perform simulations of the molecules docking and dynamics to better understand the molecular mechanism of action of the cathepsin S inhibitor RO5444101. Furthermore BI-1124 has a superior PK profile and showed dose-dependent inhibition of the ovalbumin induced IL-2 secretion in a T cell receptor transgenic DO11 mouse model with an IC 50 of 03 mgkg. Cathepsin S a lysosomal cysteine protease plays an important role in antigen presentation. Cathepsin S is a lysosomal cysteine protease playing an important role in antigen presentation.
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To date several classes of Cat S inhibitors have been reported many of which form. Sena BF 1 Figueiredo JL 2 Aikawa E 3. MCE has not independently confirmed the accuracy of these methods. - Find MSDS or SDS a COA data sheets and more information. Cathepsin S Inhibitor - Calbiochem Cathepsin S Inhibitor is a slow tight-binding reversible inhibitor of cathepsin S Ki 185 pM.
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BI-1915 is a highly potent inhibitor of Cathepsin S IC 50 17 nM for in vitro use that effectively blocks the specific ovalbumin induced IL-2 secretion in T-cells with an EC 50 value of 28 nM and shows excellent selectivity against related cathepsins with IC 50 values of 10 µM. Cathepsin S inhibitor is a novel Cathepsin S inhibitor. Cathepsin S inhibitors prevent presentation of antigen from different MHC-II haplotypes 84 and they may be considered as therapeutic targets to reduce the inflammatory response in atherosclerosis. See customer reviews validations product citations. This antibody is tested and proven to work in the following applications.
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