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Cytolytic Activity. A hemolytic activity secreted by the endotoxin-challenged. We hypothesized that since cytotoxic T cells release cytolytic proteins such as perforin PRF1 and pro-apoptotic granzymes GZMA to attack cancer cells a cytolytic activity score CYT would be a useful tool to assess anticancer immunity. Cytolytic activity indirectly reflected by the extent of peri-tumor edema may provide a. We hypothesized that CYT-high hepatocellular carcinomas HCCs have stronger immunogenicity and favorable tumor microenvironments which would result in better clinical outcomes using the cancer genome atlas TCGA cohort with 371 patients with HCC.
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16 To test whether L-glu-L-trp antitumor activity depended on intact cytolytic machinery in vivo the response of LLC xenograft growth in C57BL6 Lyst –. The cytolytic activity of the secretion was assayed by the lysis of sheep erythrocytes using methods described previously 2. Cytolytic activity can be induced in CTLp by any of a number of antigens including major and minor histocompatibility antigens hapten-modified syngeneic cells virus-infected cells or cells infected with other intracellular pathogens. Immune Cytolytic Activity Varies across Tumor Types and Is Associated with Suppressive Factors A Cytolytic activity CYT defined as the log-average geometric mean of GZMA and PRF1 expression in transcripts per million TPM is shown for each of. We hypothesized that CYT-high hepatocellular carcinomas HCCs have stronger immunogenicity and favorable tumor microenvironments which would result in better clinical outcomes using the cancer genome atlas TCGA cohort with 371 patients with HCC. Cytolytic activity differs across established PDA subtypes To classify the subpopulations of PDA tumors with high versus low cytolytic activity we stratified the PDA dataset by defining tumors in the top 10th percentile by cytolytic index as cytolytic-high CYT High and tumors in the bottom 25th percentile as cytolytic-low CYT Low.
Impaired NK-cell cytolytic activity together with other laboratory trends including elevated sCD25 were consistent with a hyperinflammatory state in keeping with macrophage-activation syndrome.
We hypothesized that since cytotoxic T cells release cytolytic proteins such as perforin PRF1 and pro-apoptotic granzymes GZMA to attack cancer cells a cytolytic activity score CYT would be a useful tool to assess anticancer immunity. We hypothesized that CYT-high hepatocellular carcinomas HCCs have stronger immunogenicity and favorable tumor microenvironments which would result in better clinical outcomes using the cancer genome atlas TCGA cohort with 371 patients with HCC. Cytolytic activity can be induced in CTLp by any of a number of antigens including major and minor histocompatibility antigens hapten-modified syngeneic cells virus-infected cells or cells infected with other intracellular pathogens. Genomic expression data were obtained from 456 patients from The Cancer Genome Atlas TCGA. Cytolytic activity indirectly reflected by the extent of peri-tumor edema may provide a. The cytolytic activity CYT score associations with molecular subtypes high mutation load and immune checkpoint molecules in gastric cancer GC.
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The cytolytic activity of CD94-expressing cells depends at least partially on NKG2D-activating NKR because anti-NKG2D mAb suppressed this activity. A hemolytic activity secreted by the endotoxin-challenged. We hypothesized that CYT-high hepatocellular carcinomas HCCs have stronger immunogenicity and favorable tumor microenvironments which would result in better clinical outcomes using the cancer genome atlas TCGA cohort with 371 patients with HCC. The dissolution or destruction of a cell. The cytolytic activity CYT score associations with molecular subtypes high mutation load and immune checkpoint molecules in gastric cancer GC.
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The cytolytic activity of CD94-expressing cells depends at least partially on NKG2D-activating NKR because anti-NKG2D mAb suppressed this activity. American Heritage Dictionary of the English Language Fifth Edition. However it is possible that other receptors that were not analyzed in this study are involved in the killing activity. Immune Cytolytic Activity Varies across Tumor Types and Is Associated with Suppressive Factors A Cytolytic activity CYT defined as the log-average geometric mean of GZMA and PRF1 expression in transcripts per million TPM is shown for each of. A hemolytic activity secreted by the endotoxin-challenged.
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T-lymphocytes were activated by monocyte-derived. The cytolytic activity CYT score associations with molecular subtypes high mutation load and immune checkpoint molecules in gastric cancer GC. Cytolytic activity CYT score is a prognostic biomarker reflecting host immune status in hepatocellular carcinoma HCC Hiroaki Wakiyama Takaaki Masuda Yushi Motomura H. Impaired NK-cell cytolytic activity together with other laboratory trends including elevated sCD25 were consistent with a hyperinflammatory state in keeping with macrophage-activation syndrome. Cytolytic activity score CYT defined by granzyme A and perforin expression is a useful marker for underlying immunity.
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We also showed that high CYT levels are accompanied by upregulation of at least one immune-checkpoint molecule indicating that immune responses in CYT-high tumors elicit immune suppression in the tumor microenvironment 28. 99100 based on 7 PubMed citations. Cytolytic activity differs across established PDA subtypes To classify the subpopulations of PDA tumors with high versus low cytolytic activity we stratified the PDA dataset by defining tumors in the top 10th percentile by cytolytic index as cytolytic-high CYT High and tumors in the bottom 25th percentile as cytolytic-low CYT Low. We hypothesized that CYT-high hepatocellular carcinomas HCCs have stronger immunogenicity and favorable tumor microenvironments which would result in better clinical outcomes using the cancer genome atlas TCGA cohort with 371 patients with HCC. Cytolytic activity indirectly reflected by the extent of peri-tumor edema may provide a.
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Our results highlighted the immunoregulatory mechanism heterogeneity of gliomas. Impaired NK-cell cytolytic activity together with other laboratory trends including elevated sCD25 were consistent with a hyperinflammatory state in keeping with macrophage-activation syndrome. The CYT is assessed by granzyme A GZMA and perforin-1 PRF1 which is dramatically reflected the activation of CD8 T cell and immune status 11 12. The cytolytic activity CYT score associations with molecular subtypes high mutation load and immune checkpoint molecules in gastric cancer GC. ATCC cytolytic activity against hsv 2 infected Cytolytic Activity Against Hsv 2 Infected supplied by ATCC used in various techniques.
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American Heritage Dictionary of the English Language Fifth Edition. Cytolytic synonyms cytolytic pronunciation cytolytic translation English dictionary definition of cytolytic. American Heritage Dictionary of the English Language Fifth Edition. Cytolytic activity was shown to associate with improved survival in CRC due to increased immunity and cytolytic activity of T cells and M1 macrophages. Cytolytic activity indirectly reflected by the extent of peri-tumor edema may provide a.
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CYT was defined by GZMA and PRF1 expression. Cytolytic activity can be induced in CTLp by any of a number of antigens including major and minor histocompatibility antigens hapten-modified syngeneic cells virus-infected cells or cells infected with other intracellular pathogens. T-lymphocytes were activated by monocyte-derived. A hemolytic activity secreted by the endotoxin-challenged. Qingjiang Taro Tobo Hidetoshi Eguchi Katsumi Sakamoto Masakazu Hirakawa Hiroshi Honda Koshi Mimori.
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99100 based on 7 PubMed citations. Genomic expression data were obtained from 456 patients from The Cancer Genome Atlas TCGA. A CYT score in The Cancer Genome Atlas TCGA molecular subtypes. We hypothesized that CYT-high hepatocellular carcinomas HCCs have stronger immunogenicity and favorable tumor microenvironments which would result in better clinical outcomes using the cancer genome atlas TCGA cohort with 371 patients with HCC. In this study we attempted to improve the cytolytic activity of effector T-lymphocytes against HCC.
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American Heritage Dictionary of the English Language Fifth Edition. Impaired NK-cell cytolytic activity together with other laboratory trends including elevated sCD25 were consistent with a hyperinflammatory state in keeping with macrophage-activation syndrome. We also showed that high CYT levels are accompanied by upregulation of at least one immune-checkpoint molecule indicating that immune responses in CYT-high tumors elicit immune suppression in the tumor microenvironment 28. American Heritage Dictionary of the English Language Fifth Edition. We hypothesized that since cytotoxic T cells release cytolytic proteins such as perforin PRF1 and pro-apoptotic granzymes GZMA to attack cancer cells a cytolytic activity score CYT would be a useful tool to assess anticancer immunity.
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Cytolytic activity indirectly reflected by the extent of peri-tumor edema may provide a. We hypothesized that since cytotoxic T cells release cytolytic proteins such as perforin PRF1 and pro-apoptotic granzymes GZMA to attack cancer cells a cytolytic activity score CYT would be a useful tool to assess anticancer immunity. A simple and quantitative formula to estimate the immune cytolytic activity CYT of glioma was proposed by Rooney et al. We also showed that high CYT levels are accompanied by upregulation of at least one immune-checkpoint molecule indicating that immune responses in CYT-high tumors elicit immune suppression in the tumor microenvironment 28. The proper trafficking and exocytosis of the cytolytic granules is disrupted by a mutation of the Lyst gene in beige mice.
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American Heritage Dictionary of the English Language Fifth Edition. Immune Cytolytic Activity Varies across Tumor Types and Is Associated with Suppressive Factors A Cytolytic activity CYT defined as the log-average geometric mean of GZMA and PRF1 expression in transcripts per million TPM is shown for each of. ATCC cytolytic activity against hsv 2 infected Cytolytic Activity Against Hsv 2 Infected supplied by ATCC used in various techniques. Cytolytic activity CYT score is a prognostic biomarker reflecting host immune status in hepatocellular carcinoma HCC Hiroaki Wakiyama Takaaki Masuda Yushi Motomura H. T-lymphocytes were activated by monocyte-derived.
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Our findings suggest that impaired counts and cytolytic activity of NK cells are important characteristics of severe COVID-19 and can potentially facilitate strategies for immunomodulatory therapies. The cytolytic activity of the secretion was assayed by the lysis of sheep erythrocytes using methods described previously 2. The CYT is assessed by granzyme A GZMA and perforin-1 PRF1 which is dramatically reflected the activation of CD8 T cell and immune status 11 12. We hypothesized that since cytotoxic T cells release cytolytic proteins such as perforin PRF1 and pro-apoptotic granzymes GZMA to attack cancer cells a cytolytic activity score CYT would be a useful tool to assess anticancer immunity. Impaired NK-cell cytolytic activity together with other laboratory trends including elevated sCD25 were consistent with a hyperinflammatory state in keeping with macrophage-activation syndrome.
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A CYT score in The Cancer Genome Atlas TCGA molecular subtypes. Immune Cytolytic Activity Varies across Tumor Types and Is Associated with Suppressive Factors A Cytolytic activity CYT defined as the log-average geometric mean of GZMA and PRF1 expression in transcripts per million TPM is shown for each of. Cytolytic activity score CYT defined by granzyme A and perforin expression is a useful marker for underlying immunity. Cytolytic activity indirectly reflected by the extent of peri-tumor edema may provide a. Genomic expression data were obtained from 456 patients from The Cancer Genome Atlas TCGA.
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Our results highlighted the immunoregulatory mechanism heterogeneity of gliomas. Qingjiang Taro Tobo Hidetoshi Eguchi Katsumi Sakamoto Masakazu Hirakawa Hiroshi Honda Koshi Mimori. Immune cytolytic activity was significantly positively associated with the extent of peri-tumor edema and was independently correlated with reduced survival time. The cytolytic activity of CD94-expressing cells depends at least partially on NKG2D-activating NKR because anti-NKG2D mAb suppressed this activity. We hypothesized that since cytotoxic T cells release cytolytic proteins such as perforin PRF1 and pro-apoptotic granzymes GZMA to attack cancer cells a cytolytic activity score CYT would be a useful tool to assess anticancer immunity.
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We hypothesized that since cytotoxic T cells release cytolytic proteins such as perforin PRF1 and pro-apoptotic granzymes GZMA to attack cancer cells a cytolytic activity score CYT would be a useful tool to assess anticancer immunity. However it is possible that other receptors that were not analyzed in this study are involved in the killing activity. Qingjiang Taro Tobo Hidetoshi Eguchi Katsumi Sakamoto Masakazu Hirakawa Hiroshi Honda Koshi Mimori. We also showed that high CYT levels are accompanied by upregulation of at least one immune-checkpoint molecule indicating that immune responses in CYT-high tumors elicit immune suppression in the tumor microenvironment 28. Cytolytic activity differs across established PDA subtypes To classify the subpopulations of PDA tumors with high versus low cytolytic activity we stratified the PDA dataset by defining tumors in the top 10th percentile by cytolytic index as cytolytic-high CYT High and tumors in the bottom 25th percentile as cytolytic-low CYT Low.
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We also showed that high CYT levels are accompanied by upregulation of at least one immune-checkpoint molecule indicating that immune responses in CYT-high tumors elicit immune suppression in the tumor microenvironment 28. A simple and quantitative formula to estimate the immune cytolytic activity CYT of glioma was proposed by Rooney et al. ATCC cytolytic activity against hsv 2 infected Cytolytic Activity Against Hsv 2 Infected supplied by ATCC used in various techniques. We also showed that high CYT levels are accompanied by upregulation of at least one immune-checkpoint molecule indicating that immune responses in CYT-high tumors elicit immune suppression in the tumor microenvironment 28. The cytolytic activity CYT score associations with molecular subtypes high mutation load and immune checkpoint molecules in gastric cancer GC.
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Our results highlighted the immunoregulatory mechanism heterogeneity of gliomas. The cytolytic activity CYT score associations with molecular subtypes high mutation load and immune checkpoint molecules in gastric cancer GC. The cytolytic activity of CD94-expressing cells depends at least partially on NKG2D-activating NKR because anti-NKG2D mAb suppressed this activity. A simple and quantitative formula to estimate the immune cytolytic activity CYT of glioma was proposed by Rooney et al. Cytolytic activity indirectly reflected by the extent of peri-tumor edema may provide a.
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We hypothesized that since cytotoxic T cells release cytolytic proteins such as perforin PRF1 and pro-apoptotic granzymes GZMA to attack cancer cells a cytolytic activity score CYT would be a useful tool to assess anticancer immunity. A hemolytic activity secreted by the endotoxin-challenged. A simple and quantitative formula to estimate the immune cytolytic activity CYT of glioma was proposed by Rooney et al. ATCC cytolytic activity against hsv 2 infected Cytolytic Activity Against Hsv 2 Infected supplied by ATCC used in various techniques. We also showed that high CYT levels are accompanied by upregulation of at least one immune-checkpoint molecule indicating that immune responses in CYT-high tumors elicit immune suppression in the tumor microenvironment 28.
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