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Divalent metal transporter

Written by Wayne Jun 01, 2021 · 9 min read
Divalent metal transporter

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Divalent Metal Transporter. Proc Natl Acad Sci USA 2008. In 1997 parallel experiments from two groups provided compelling evidence of its function. To determine whether DMT1 is. 513 Views 70 CrossRef citations to date Altmetric Iron Metabolism Divalent metal transporter 1.

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We have determined a 29 angstrom resolution structure of CorA from Thermotoga maritima that reveals a pentameric coneshaped protein. Iron is required in a variety of essential processes in the body. DMT1 locates to cellular membranes and endosomal membranes where it is a key player in non-transferrin bound iron uptake and transferrin-bound iron uptake respectively. Hematology Volume 10 2005 - Issue 4. P0A769 Interaction i Binary interactions i. CAS Article Google Scholar.

In this review we focus on iron transport in the brain and the role of the divalent metal transporter 1 DMT1 vital for iron uptake in most cells.

It is a widely expressed H -coupled divalent metal ion transporter that accepts a variety of divalent metal ions. Can probably also transport cadmium cobalt copper and zinc but not iron. May be the predominant transporter of manganese during logarithmic phase growth. P0A769 Interaction i Binary interactions i. 513 Views 70 CrossRef citations to date Altmetric Iron Metabolism Divalent metal transporter 1. Divalent metal transporter 1 DMT1 contributes to neurodegeneration in animal models of Parkinsons disease.

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Involved in manganese uptake. Divalent metal transporter 1 DMT1 also known as natural resistance associated macrophage protein 2 Nramp2 is a widely expressed transmembrane protein. The divalent metal transporter 1 DMT1 is a multimetal transporter with a primary role in iron transport. Indeed recent mechanistic studies found that the intestinal transporter for nonheme iron divalent metal transporter 1 DMT1 mediates the transport of Pb and Cd. DMT1 is regulated in part by dietary iron and chemical species of Cd and Pb that are transported by DMT1 would be made available through digestion and are also found in plasma.

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The transporter that mediates the uptake into enterocytes on the apical side is the divalent metal transporter DMT1. IRON METABOLISM Divalent metal transporter 1 MARTHA P. Divalent metal transporter 1 DMT1 contributes to neurodegeneration in animal models of Parkinsons disease. H-stimulated divalent metal cation uptake system. CorA family members are ubiquitously distributed transporters of divalent metal cations and are considered to be the primary Mg2 transporter of Bacteria and Archaea.

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Indeed recent mechanistic studies found that the intestinal transporter for nonheme iron divalent metal transporter 1 DMT1 mediates the transport of Pb and Cd. H-stimulated divalent metal cation uptake system. Divalent metal transporter 1 DMT1 is the first mammalian transmembrane iron transporter to be identified. Recently we identified divalent cation transporter 1divalent metal ion transporter 1 DCT1DMT1 as the major intestinal iron absorptive mechanism. Hematology Volume 10 2005 - Issue 4.

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CorA family members are ubiquitously distributed transporters of divalent metal cations and are considered to be the primary Mg2 transporter of Bacteria and Archaea. May be the predominant transporter of manganese during logarithmic phase growth. P0A769 Interaction i Binary interactions i. MIMS 1 JOSEF T. CAS Article Google Scholar.

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513 Views 70 CrossRef citations to date Altmetric Iron Metabolism Divalent metal transporter 1. MIMS 1 JOSEF T. Iron is required in a variety of essential processes in the body. It is a widely expressed H -coupled divalent metal ion transporter that accepts a variety of divalent metal ions. CAS Article Google Scholar.

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Much of iron and manganese metabolism occurs in mitochondria. In 1997 parallel experiments from two groups provided compelling evidence of its function. Divalent metal cation transporter MntH Add BLAST. IRON METABOLISM Divalent metal transporter 1 MARTHA P. DMT1 locates to cellular membranes and endosomal membranes where it is a key player in non-transferrin bound iron uptake and transferrin-bound iron uptake respectively.

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The divalent metal transporter 1 DMT1 is a multimetal transporter with a primary role in iron transport. It is a widely expressed H -coupled divalent metal ion transporter that accepts a variety of divalent metal ions. Divalent metal transporter 1 Search in. Submit an article Journal homepage. To determine whether DMT1 is.

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Recently we identified divalent cation transporter 1divalent metal ion transporter 1 DCT1DMT1 as the major intestinal iron absorptive mechanism. Depending on the presence or absence of. P0A769 Interaction i Binary interactions i. It is a widely expressed H -coupled divalent metal ion transporter that accepts a variety of divalent metal ions. Protein-protein interaction databases.

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513 Views 70 CrossRef citations to date Altmetric Iron Metabolism Divalent metal transporter 1. CAS Article Google Scholar. Hematology Volume 10 2005 - Issue 4. Accepted 7 February 2005 Abstract In the last few years the Þeld of iron metabolism has exploded with the discoveryof many new proteins including. In this review we focus on iron transport in the brain and the role of the divalent metal transporter 1 DMT1 vital for iron uptake in most cells.

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The transporter that mediates the uptake into enterocytes on the apical side is the divalent metal transporter DMT1. CAS Article Google Scholar. CorA family members are ubiquitously distributed transporters of divalent metal cations and are considered to be the primary Mg2 transporter of Bacteria and Archaea. Therefore iron must be maintained or reduced to its divalent Fe 2 form by the ferrireductase duodenal cytochrome b Dcytb. Divalent metal transporter 1 DMT1 is the first mammalian transmembrane iron transporter to be identified.

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IRON METABOLISM Divalent metal transporter 1 MARTHA P. Although DMT1 has been described previously in the CNS nothing was known about the role of this metal transporter in oligodendrocyte maturation and myelination. IRON METABOLISM Divalent metal transporter 1 MARTHA P. Divalent metal transporter DMT Fig. Recently we identified divalent cation transporter 1divalent metal ion transporter 1 DCT1DMT1 as the major intestinal iron absorptive mechanism.

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DMT1 is regulated in part by dietary iron and chemical species of Cd and Pb that are transported by DMT1 would be made available through digestion and are also found in plasma. MIMS 1 JOSEF T. The vertebrate divalent metal transporter-1 DMT-1 contributes to maintaining cellular Mn 2 homeostasis and has recently been implicated in Fe 2-mediated neurodegeneration in PD. It is a widely expressed H -coupled divalent metal ion transporter that accepts a variety of divalent metal ions. In this study we describe a novel model for manganism that incorporates the genetically tractable nematode Caenorhabditis elegans.

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PRCHAL 12 1 Division of HematologyOncology Baylor College of Medicine Houston TX and 2 Houston VA Medical Center Houston TX Received 10 January 2005. We have determined a 29 angstrom resolution structure of CorA from Thermotoga maritima that reveals a pentameric coneshaped protein. Recently we identified divalent cation transporter 1divalent metal ion transporter 1 DCT1DMT1 as the major intestinal iron absorptive mechanism. Involved in manganese uptake. Hematology Volume 10 2005 - Issue 4.

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Divalent metal transporter 1 Search in. 27 The nonheme iron in the lumen of the gut has variable solubility depending on the various amounts of ferric and ferrous iron and the amounts. 9-1 is a transmembrane protein that resides on the luminal membrane has a strong preference for divalent metals and exists in several isoforms DMT1 and DMT2. Proc Natl Acad Sci USA 2008. 513 Views 70 CrossRef citations to date Altmetric Iron Metabolism Divalent metal transporter 1.

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Uptake of redox-active iron must be tightly controlled but little is known about how metal ions enter mitochondria. Uptake of redox-active iron must be tightly controlled but little is known about how metal ions enter mitochondria. Recently we identified divalent cation transporter 1divalent metal ion transporter 1 DCT1DMT1 as the major intestinal iron absorptive mechanism. The vertebrate divalent metal transporter-1 DMT-1 contributes to maintaining cellular Mn 2 homeostasis and has recently been implicated in Fe 2-mediated neurodegeneration in PD. Fleming and colleagues identified mutations in DMT1 formerly known as Nramp2 and DCT1 in mice and.

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To determine whether DMT1 is. DMT1 locates to cellular membranes and endosomal membranes where it is a key player in non-transferrin bound iron uptake and transferrin-bound iron uptake respectively. Iron is required in a variety of essential processes in the body. Divalent metal transporter DMT Fig. DMT1 is regulated in part by dietary iron and chemical species of Cd and Pb that are transported by DMT1 would be made available through digestion and are also found in plasma.

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Divalent metal transporter 1 DMT1 contributes to neurodegeneration in animal models of Parkinsons disease. Fleming and colleagues identified mutations in DMT1 formerly known as Nramp2 and DCT1 in mice and. CAS Article Google Scholar. In 1997 parallel experiments from two groups provided compelling evidence of its function. Divalent metal cation transporter MntH Add BLAST.

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Indeed recent mechanistic studies found that the intestinal transporter for nonheme iron divalent metal transporter 1 DMT1 mediates the transport of Pb and Cd. Uptake of redox-active iron must be tightly controlled but little is known about how metal ions enter mitochondria. Depending on the presence or absence of. To determine whether DMT1 is. Involved in manganese uptake.

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