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Duf1220. DUF1220 proteins regions show the largest Homosapiens lineage-specific increase in copy number of any protein-coding region in the human genome and map principally to 1q211 and partially also in 1p. DUF1220 protein domains are approximately 65 amino acids in length and have undergone unusually rapid and extensive copy-number expansion during recent primate evolution and most strikingly in the human lineage. DUF1220 sequences have now been linked to human brain expansion autism severity total IQ and cognitive and mathematical aptitude scores. Dophins are regarded as one of earths most intelligent.
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We supplemented by analyzing. DUF1220 sequences have now been linked to human brain expansion autism severity total IQ and cognitive and mathematical aptitude scores. The same gene family that may have helped the human brain become larger and more complex than in any other animal also is linked to the severity of autism according to new. DUF1220 protein domains exhibit the most extreme human lineagespecific HLS copy number increase of any protein coding region in the human genome and have recently been linked to evolutionary and pathological changes in brain size eg. These findings lend support to the view that DUF1220 domain dosage is a key factor in the determination of primate. DUF1220 protein domains are approximately 65 amino acids in length and have undergone unusually rapid and extensive copy-number expansion during recent primate evolution and most strikingly in the human lineage.
The copy number of DUF1220 a protein domain implicated in human brain evolution has been linearly associated with autism severity.
DUF1220 is a protein domain encoded almost exclusively by genes of the neuroblastoma breakpoint family NBPF on chromosome 1q21. DUF1220 protein domains exhibit the most extreme human lineagespecific HLS copy number increase of any protein coding region in the human genome and have recently been linked to evolutionary and pathological changes in brain size eg. The copy number of DUF1220 a protein domain implicated in human brain evolution has been linearly associated with autism severity. It correlates with brain size and number of neurons in the neocortex. We analyzed in chromosome 1q a large region of 218 contiguous DUF1220 as well as in the chromosome 1p five other regions of DUF1220 smaller then a total of 245 DUF1220 proteins. DUF1220 proteins regions show the largest Homosapiens lineage-specific increase in copy number of any protein-coding region in the human genome and map principally to 1q211 and partially also in 1p.
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Sikelas team found that DNA sequences that encode DUF1220 domains show the largest human-specific increase in copy number of any gene sequences in the human genome. This mysterious fragment is called domain of unknown function 1220 or DUF1220 yes there are thousands of domains without known functions. Obligatory Simpsons beer references aside DUF1220. New study on DUF1220. 9 10 11 This region has.
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The number of Duf 1220 copies rises with increasing cognitive sophistication of the animal. 1 The first DUF1220-encoding gene identified as a dramatic human-lineage-specific HLS increase in copy number was MGC8902 cDNA IMAGE 843276 and was the. The copy number of DUF1220 a protein domain implicated in human brain evolution has been linearly associated with autism severity. We analyzed in chromosome 1q a large region of 218 contiguous DUF1220 as well as in the chromosome 1p five other regions of DUF1220 smaller then a total of 245 DUF1220 proteins. This mysterious fragment is called domain of unknown function 1220 or DUF1220 yes there are thousands of domains without known functions.
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