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Hub Genes. The aim of this study was to identify the hub genes based on protein-protein interaction network and uncover their clinical value. Then the 10 hub genes were combined from the 4 time points and duplicate genes were removed to obtain a total of 17 hub genes. As indicated in the clustering heat map Fig. In this study we extracted 21 hub genes with a high correlation with the yellow module Fig.
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A total of seven genes with degrees 10 was identified as hub genes. The team show that hub genes are conserved in other organisms and suggest that their normal function is to act as genetic buffers minimizing the effects of. Research should be published in open access ie. This small group of genes called hub genes was found in a study of interaction in the nematode worm C. These hub genes and key pathways could improve our understanding of the process of tumorigenesis and the underlying molecular events and may be therapeutic targets for the precise treatment of these two subtypes with different. The pathogenic mechanisms of prostate cancer PCa remain to be defined.
Subsequently we constructed a PPI network using Cytoscape and we screened these 21 PPI hub genes exhibiting intimate interactions with other genes Fig.
Ten hub genes were screened at each time point. These hub genes and key pathways could improve our understanding of the process of tumorigenesis and the underlying molecular events and may be therapeutic targets for the precise treatment of these two subtypes with different. As indicated in the clustering heat map Fig. The team show that hub genes are conserved in other organisms and suggest that their normal function is to act as genetic buffers minimizing the effects of. Six hub genes CCNB2 CDC20 CEP55 KIF20A TOP2A and UBE2C were identified in both co-expression and protein-protein interaction PPI networks which were highly correlated with pathologic stage. The aim of this study was to identify the hub genes based on protein-protein interaction network and uncover their clinical value.
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The results of multiple verification methods indicated that the 11 hub genes had highly diagnostic efficiencies to distinguish tumors from normal tissues. Hsa-miR-29c hsa-miR-30c hsa-miR-335 hsa-miR-33b and hsa-miR-101 might play a crucial role in hub genes regulation. Twelve genes were considered as hub genes owing to high degrees in the network. As expected functional annotation obtained from Metascape suggested that hub genes were mainly enriched in peptide cross-linking response to mechanical stimulus and regulation of vasculature. Then the 10 hub genes were combined from the 4 time points and duplicate genes were removed to obtain a total of 17 hub genes.
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HUB Genes Involving in SCI. As indicated in the clustering heat map Fig. Twelve genes were considered as hub genes owing to high degrees in the network. A total of seven genes with degrees 10 was identified as hub genes. The Open Access is a new and advanced form of scientific communication which is going to replace outdated subscription models.
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In addition the transcription factors-hub genes. The significance of expression of the hub genes in ccRCC was ranked top 4 among all cancers and correlated with poor prognosis. Four hub genes COL6A3 CRISPLD2 FBN1 and SERPINF1 were identified to be associated with the prognosis in OvCa which might be used as monitoring biomarkers to evaluate survival time of OvCa patients. Six hub genes CCNB2 CDC20 CEP55 KIF20A TOP2A and UBE2C were identified in both co-expression and protein-protein interaction PPI networks which were highly correlated with pathologic stage. Hsa-miR-29c hsa-miR-30c hsa-miR-335 hsa-miR-33b and hsa-miR-101 might play a crucial role in hub genes regulation.
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Ten hub genes were screened at each time point. Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis. Four hub genes COL6A3 CRISPLD2 FBN1 and SERPINF1 were identified to be associated with the prognosis in OvCa which might be used as monitoring biomarkers to evaluate survival time of OvCa patients. The pathogenic mechanisms of prostate cancer PCa remain to be defined. A total of seven genes with degrees 10 was identified as hub genes.
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Identification of hub genes of modules and filtration via the PPI network. Furthermore we identified 11 hub genes MCM3 TRMT6 AURKA CDC20 TOP2A ECT2 TK1 MCM2 FEN1 NCAPD2 and KPNA2 which played key roles in HCC. DEGs and hub genes identified in the present investigation help us understand the molecular mechanisms underlying the advancement of T1D and provide candidate targets for diagnosis and treatment of T1D. 8b the hub genes could well distinguish the IgAN and control group in monocyte sample. Genes located in the central position of a gene-gene interaction network likely exhibit more important functions than other genes.
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Detailed information on hub genes including gene symbols degrees full names and gene function was shown in Table 1. These hub genes and key pathways could improve our understanding of the process of tumorigenesis and the underlying molecular events and may be therapeutic targets for the precise treatment of these two subtypes with different. Although hundreds of colorectal cancer- CRC- related genes have been screened the significant hub genes still need to be further identified. Twelve genes were considered as hub genes owing to high degrees in the network. As expected functional annotation obtained from Metascape suggested that hub genes were mainly enriched in peptide cross-linking response to mechanical stimulus and regulation of vasculature.
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Agt Anxal C3 C3ar1 C5ar1 CaSR Cx3cl1 Cxcl1 Cxcl10 Cxcl2 Gabbr1 Gnai1 Gnb5 Gng8 Penk Pf4 and Psap. This small group of genes called hub genes was found in a study of interaction in the nematode worm C. Furthermore we identified 11 hub genes MCM3 TRMT6 AURKA CDC20 TOP2A ECT2 TK1 MCM2 FEN1 NCAPD2 and KPNA2 which played key roles in HCC. A total of seven genes with degrees 10 was identified as hub genes. Although hundreds of colorectal cancer- CRC- related genes have been screened the significant hub genes still need to be further identified.
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In addition the transcription factors-hub genes. The aim of this study was to identify the hub genes based on protein-protein interaction network and uncover their clinical value. The Open Access is a new and advanced form of scientific communication which is going to replace outdated subscription models. In addition the transcription factors-hub genes. Gene set enrichment analysis was also employed to identify the intersection of the key pathways JAK-STAT FOXO and NF-κB pathways validated in the above analyses.
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The pathogenic mechanisms of prostate cancer PCa remain to be defined. Agt Anxal C3 C3ar1 C5ar1 CaSR Cx3cl1 Cxcl1 Cxcl10 Cxcl2 Gabbr1 Gnai1 Gnb5 Gng8 Penk Pf4 and Psap. Although hundreds of colorectal cancer- CRC- related genes have been screened the significant hub genes still need to be further identified. As expected functional annotation obtained from Metascape suggested that hub genes were mainly enriched in peptide cross-linking response to mechanical stimulus and regulation of vasculature. DEGs and hub genes identified in the present investigation help us understand the molecular mechanisms underlying the advancement of T1D and provide candidate targets for diagnosis and treatment of T1D.
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A total of seven genes with degrees 10 was identified as hub genes. The scatter plot showed that each hub gene was significantly different between the IgAN and control group Fig. Hsa-miR-29c hsa-miR-30c hsa-miR-335 hsa-miR-33b and hsa-miR-101 might play a crucial role in hub genes regulation. Six hub genes CCNB2 CDC20 CEP55 KIF20A TOP2A and UBE2C were identified in both co-expression and protein-protein interaction PPI networks which were highly correlated with pathologic stage. As indicated in the clustering heat map Fig.
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The significance of expression of the hub genes in ccRCC was ranked top 4 among all cancers and correlated with poor prognosis. This small group of genes called hub genes was found in a study of interaction in the nematode worm C. The scatter plot showed that each hub gene was significantly different between the IgAN and control group Fig. A total of seven genes with degrees 10 was identified as hub genes. As indicated in the clustering heat map Fig.
Source: pinterest.com
As expected functional annotation obtained from Metascape suggested that hub genes were mainly enriched in peptide cross-linking response to mechanical stimulus and regulation of vasculature. This small group of genes called hub genes was found in a study of interaction in the nematode worm C. Four hub genes COL6A3 CRISPLD2 FBN1 and SERPINF1 were identified to be associated with the prognosis in OvCa which might be used as monitoring biomarkers to evaluate survival time of OvCa patients. Although hundreds of colorectal cancer- CRC- related genes have been screened the significant hub genes still need to be further identified. Furthermore we identified 11 hub genes MCM3 TRMT6 AURKA CDC20 TOP2A ECT2 TK1 MCM2 FEN1 NCAPD2 and KPNA2 which played key roles in HCC.
Source: pinterest.com
Research should be published in open access ie. Furthermore we identified 11 hub genes MCM3 TRMT6 AURKA CDC20 TOP2A ECT2 TK1 MCM2 FEN1 NCAPD2 and KPNA2 which played key roles in HCC. A total of seven genes with degrees 10 was identified as hub genes. The Sci-Hub project supports Open Access movement in science. Identification of hub genes of modules and filtration via the PPI network.
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We identified four hub genes ie TOP2A TTK CHEK1 and CENPA in the network center related to gene regulation and possible carcinogenesis. 8b the hub genes could well distinguish the IgAN and control group in monocyte sample. Subsequently we constructed a PPI network using Cytoscape and we screened these 21 PPI hub genes exhibiting intimate interactions with other genes Fig. DEGs and hub genes identified in the present investigation help us understand the molecular mechanisms underlying the advancement of T1D and provide candidate targets for diagnosis and treatment of T1D. Identification of hub genes in prostate cancer using robust rank aggregation and weighted gene co-expression network analysis.
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HUB Genes Involving in SCI. A total of seven genes with degrees 10 was identified as hub genes. Identification of hub genes of modules and filtration via the PPI network. HUB Genes Involving in SCI. We identified four hub genes ie TOP2A TTK CHEK1 and CENPA in the network center related to gene regulation and possible carcinogenesis.
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The Open Access is a new and advanced form of scientific communication which is going to replace outdated subscription models. As indicated in the clustering heat map Fig. The Sci-Hub project supports Open Access movement in science. The Open Access is a new and advanced form of scientific communication which is going to replace outdated subscription models. Be free to read.
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A total of seven genes with degrees 10 was identified as hub genes. Genes located in the central position of a gene-gene interaction network likely exhibit more important functions than other genes. HUB Genes Involving in SCI. As indicated in the clustering heat map Fig. The team show that hub genes are conserved in other organisms and suggest that their normal function is to act as genetic buffers minimizing the effects of.
Source: pinterest.com
As expected functional annotation obtained from Metascape suggested that hub genes were mainly enriched in peptide cross-linking response to mechanical stimulus and regulation of vasculature. As expected functional annotation obtained from Metascape suggested that hub genes were mainly enriched in peptide cross-linking response to mechanical stimulus and regulation of vasculature. In this study we utilized the Robust Rank Aggregation RRA method to integrate 10 eligible PCa microarray datasets from the GEO and identified a set. The pathogenic mechanisms of prostate cancer PCa remain to be defined. As indicated in the clustering heat map Fig.
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