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Inositol 1 4 5 Trisphosphate. Triggers the release of calcium ions from special vesicles of the endoplasmic reticulum. The inositol 145-trisphosphate receptor IP3R is a major regulator of apoptotic signaling. Farlex Partner Medical Dictionary Farlex 2012. Through interactions with members of the Bcl-2 family of proteins it drives calcium Ca2 transients from the endoplasmic reticulum ER to mitochondria thereby establishing a functional and physical link between these organelles.
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Inositol 145-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cells endoplasmic reticulum. Studies utilizing genetic knockout mous. Inositol 145-trisphosphate IP 3 a second messenger formed from phosphatidylinositol 45-bisphosphate. It is produced in cells by phospholipase C PLC-mediated hydrolysis of phosphatidyl inositol-45-bisphosphate Streb et al 1983 Yoshida and Imai 1997. Inositol 145-trisphosphate IP 3 is a ubiquitous intracellular messenger regulating diverse functions in almost all mammalian cell types. Farlex Partner Medical Dictionary Farlex 2012.
These calcium ions stimulate the activity of.
Ca 2 release mediated by 3 subtypes of inositol 145-trisphosphate receptors IP 3 Rs from the endoplasmic reticulum and subsequent Ca 2 entry after endoplasmic reticulum Ca 2 store depletion has been proposed to be the major pathway to mobilize Ca 2 in endothelial cells. Inositol 145-trisphosphate IP 3 is a ubiquitous intracellular messenger regulating diverse functions in almost all mammalian cell types. May be involved in visual and olfactory transduction and myoblast proliferation PubMed1322910. Has a role in the activation of neutrophils. It is produced in cells by phospholipase C PLC-mediated hydrolysis of phosphatidyl inositol-45-bisphosphate Streb et al 1983 Yoshida and Imai 1997. Inositol 145-trisphosphate IP 3 a second messenger formed from phosphatidylinositol 45-bisphosphate.
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It is generated by membrane receptors that couple to phospholipase C PLC an enzyme which liberates IP 3 from phosphatidylinositol 45-bisphosphate PIP 2. These calcium ions stimulate the activity of. Inositol 145-trisphosphate recept. Inositol 145-trisphosphate IP 3 is a ubiquitous intracellular messenger regulating diverse functions in almost all mammalian cell types. These calcium ions stimulate the activity of B kinase or calmodulin.
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The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. The inositol 145-trisphosphate receptor IP3R is a major regulator of apoptotic signaling. Inositol 145-trisphosphate IP 3 is an important second messenger in animal cells that mediates calcium Ca 2 release from the endoplasmic reticulum ER to the cytosol 1 2 3. Inositol 145-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cells endoplasmic reticulum. This score cannot be used as a measure of the accuracy of the annotation as we cannot define the correct annotation for any given protein.
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It plays a role in basic biological functions such as cell division differentiation fertilization and cell death and is involved in developmental processes including learning memory and behavior. Studies utilizing genetic knockout mouse models have demonstrated that IP 3 Rs. Inositol 145-trisphosphate receptors IP3Rs are a family of intracellular Ca2 release channels located on the ER membrane which in mammals consist of 3 different subtypes IP3R1 IP3R2 and IP3R3 encoded by 3 genes Itpr1 Itpr2 and Itpr3 respectively. Inositol 145-trisphosphate recept. It plays a role in basic biological functions such as cell division differentiation fertilization and cell death and is involved in developmental processes including learning memory and behavior.
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In the heart however its role is largely unknown or controversial. Inositol 145-trisphosphate recept. Studies utilizing genetic knockout mous. Farlex Partner Medical Dictionary Farlex 2012. Inositol-145-trisphosphate IP3-dependent Ca2 release represents the major Ca2 mobilizing pathway responsible for diverse functions in non-excitable cells.
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The inositol 145-trisphosphate receptor IP3R is a major regulator of apoptotic signaling. The inositol 145-trisphosphate receptor IP 3 R is an intracellular ion channel that mediates the release of calcium ions from the endoplasmic reticulum. Inositol 145-trisphosphate IP 3 is a ubiquitous intracellular messenger regulating diverse functions in almost all mammalian cell types. Ca 2 release mediated by 3 subtypes of inositol 145-trisphosphate receptors IP 3 Rs from the endoplasmic reticulum and subsequent Ca 2 entry after endoplasmic reticulum Ca 2 store depletion has been proposed to be the major pathway to mobilize Ca 2 in endothelial cells. Receptor for inositol 145-trisphosphate a second messenger that mediates the release of intracellular calcium PubMed1322910.
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Studies utilizing genetic knockout mous. The three subtypes of inositol 145-trisphosphate receptors IP 3 R1 2 and 3 are intracellular Ca 2 channels that are essential for many tissues and organs. The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score cannot be used as a measure of the accuracy of the annotation as we cannot define the correct annotation for any given protein. Together with MCU has a role in oxidative stress-induced ER-mitochondria calcium transfer PubMed28726639.
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Through interactions with members of the Bcl-2 family of proteins it drives calcium Ca2 transients from the endoplasmic reticulum ER to mitochondria thereby establishing a functional and physical link between these organelles. Inositol 145-trisphosphate recept. Has a role in the activation of neutrophils. Inositol 145-trisphosphate receptors IP3Rs are a family of intracellular Ca2 release channels located on the ER membrane which in mammals consist of 3 different subtypes IP3R1 IP3R2 and IP3R3 encoded by 3 genes Itpr1 Itpr2 and Itpr3 respectively. The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome.
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It is produced in cells by phospholipase C PLC-mediated hydrolysis of phosphatidyl inositol-45-bisphosphate Streb et al 1983 Yoshida and Imai 1997. The inositol 145-trisphosphate receptor IP 3 R is a very huge intracellular Ca 2 channel tetramer of four 313 kDa channel units localized mainly on the endoplasmic reticulum. Inositol-145-trisphosphate IP3-dependent Ca2 release represents the major Ca2 mobilizing pathway responsible for diverse functions in non-excitable cells. Studies utilizing genetic knockout mous. Ca 2 release mediated by 3 subtypes of inositol 145-trisphosphate receptors IP 3 Rs from the endoplasmic reticulum and subsequent Ca 2 entry after endoplasmic reticulum Ca 2 store depletion has been proposed to be the major pathway to mobilize Ca 2 in endothelial cells.
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The inositol 145-trisphosphate receptor IP 3 R is a very huge intracellular Ca 2 channel tetramer of four 313 kDa channel units localized mainly on the endoplasmic reticulum. Farlex Partner Medical Dictionary Farlex 2012. Ca 2 release mediated by 3 subtypes of inositol 145-trisphosphate receptors IP 3 Rs from the endoplasmic reticulum and subsequent Ca 2 entry after endoplasmic reticulum Ca 2 store depletion has been proposed to be the major pathway to mobilize Ca 2 in endothelial cells. The channel is opened by a ligand inositol 145-trisphosphate IP 3 a second intracellular messenger and calcium Ca 2 is required for opening the channel. Has a role in the activation of neutrophils.
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May be involved in visual and olfactory transduction and myoblast proliferation PubMed1322910. Together with MCU has a role in oxidative stress-induced ER-mitochondria calcium transfer PubMed28726639. Inositol 145-trisphosphate receptors IP3Rs are a family of intracellular Ca2 release channels located on the ER membrane which in mammals consist of 3 different subtypes IP3R1 IP3R2 and IP3R3 encoded by 3 genes Itpr1 Itpr2 and Itpr3 respectively. It is generated by membrane receptors that couple to phospholipase C PLC an enzyme which liberates IP 3 from phosphatidylinositol 45-bisphosphate PIP 2. Terms Inositol 145-Trisphosphate Preferred Term.
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Inositol 145-trisphosphate IP 3 is an important second messenger in animal cells that mediates calcium Ca 2 release from the endoplasmic reticulum ER to the cytosol 1 2 3. Triggers the release of calcium ions from special vesicles of the endoplasmic reticulum. Inositol 145-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cells endoplasmic reticulum. It is produced in cells by phospholipase C PLC-mediated hydrolysis of phosphatidyl inositol-45-bisphosphate Streb et al 1983 Yoshida and Imai 1997. In the heart however its role is largely unknown or controversial.
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Terms Inositol 145-Trisphosphate Preferred Term. Inositol 145-trisphosphate IP 3 a second messenger formed from phosphatidylinositol 45-bisphosphate. It is produced in cells by phospholipase C PLC-mediated hydrolysis of phosphatidyl inositol-45-bisphosphate Streb et al 1983 Yoshida and Imai 1997. Through interactions with members of the Bcl-2 family of proteins it drives calcium Ca2 transients from the endoplasmic reticulum ER to mitochondria thereby establishing a functional and physical link between these organelles. These calcium ions stimulate the activity of B kinase or calmodulin.
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May be involved in visual and olfactory transduction and myoblast proliferation PubMed1322910. Farlex Partner Medical Dictionary Farlex 2012. Inositol 145-trisphosphate IP 3 is an important second messenger in animal cells that mediates calcium Ca 2 release from the endoplasmic reticulum ER to the cytosol 1 2 3. Has a role in the activation of neutrophils. These calcium ions stimulate the activity of.
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Farlex Partner Medical Dictionary Farlex 2012. This score cannot be used as a measure of the accuracy of the annotation as we cannot define the correct annotation for any given protein. Inositol 145trisphosphate receptors IP 3 Rs are a family of intracellular Ca 2 release channels located on the ER membrane which in mammals consist of 3 different subtypes IP 3 R1 IP 3 R2 and IP 3 R3 encoded by 3 genes Itpr1 Itpr2 and Itpr3 respectively. Inositol 145-trisphosphate receptors IP3Rs are a family of intracellular Ca2 release channels located on the ER membrane which in mammals consist of 3 different subtypes IP3R1 IP3R2 and IP3R3 encoded by 3 genes Itpr1 Itpr2 and Itpr3 respectively. Through interactions with members of the Bcl-2 family of proteins it drives calcium Ca2 transients from the endoplasmic reticulum ER to mitochondria thereby establishing a functional and physical link between these organelles.
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