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Pstat5. Activation can be triggered by a number of ligands including cytokines. Activation of STAT5 occurs upon phosphorylation at Tyr694. STAT5 is a transcriptional activator which is also involved in intracellular signaling. STAT5 is also critical for the maintenance of Foxp3 expression via binding the Cns2 regulatory region in Foxp3 and the suppressor phenotype of regulatory T cells.
Gm Csf Dependent Pstat5 Sensitivity Is A Feature With Therapeutic Potential In Chronic Myelomonocytic Leukemia Pubme Scientific Journal Chronic Therapeutic From pinterest.com
Validated in WB ELISA IHC and tested in Human. Immunocytochemistry Immunofluorescence - Anti-STAT5 phospho Y694 antibody ab98338 ICCIF image of ab98338 stained HepG2 cells. 7678 IL-5 signals through its high-affinity receptor IL-5Rα on the mature eosinophil to induce the phosphorylation and consequent nuclear translocation of STAT5 and the activation of the signal. The AlphaLISA SureFire Ultra p-STAT5 Tyr694699 assay is a sandwich immunoassay for quantitative detection of phospho-STAT5 phosphorylated on Tyr694699 in cellular lysates using Alpha Technology. We hypothesized that nuclear phospho-STAT5 pSTAT5 in MCs might reflect TK activation and would be a marker of abnormal MCs in SM. Phospho-Stat5 Tyr694 Antibody detects endogenous levels of Stat5a only when phosphorylated at Tyr694 and Stat5b when phosphorylated at Tyr699.
With an optimized and streamlined mix-and-read no-wash protocol the phospho-STAT5 contains all reagents you need for your research to run faster and more efficiently.
Phospho-Stat5 Tyr694 Antibody detects endogenous levels of Stat5a only when phosphorylated at Tyr694 and Stat5b when phosphorylated at Tyr699. In some cancers STAT5 is shown to be constitutively activated. STAT5 is a transcriptional activator which is also involved in intracellular signaling. Cited in 43 publications. Signal transducer and activator of transcription 5 STAT5 both STAT5A and STAT5B isoforms are expressed by human eosinophils and their signaling pathways are induced by GM-CSF and IL-5. The majority of pSTAT5 peaks contain a central palindromic GAS element TTCYXRGAA.
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2323 SM had CD25 MCs. Signal transducer and activator of transcription 5 STAT5 both STAT5A and STAT5B isoforms are expressed by human eosinophils and their signaling pathways are induced by GM-CSF and IL-5. Activation of STAT5 occurs upon phosphorylation at Tyr694. We hypothesized that nuclear phospho-STAT5 pSTAT5 in MCs might reflect TK activation and would be a marker of abnormal MCs in SM. Phospho-STAT5 alpha Tyr694 Antibody 71-6900 in WB.
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