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Quinazolinones. The N -substituted quinazolinones and related tautomerizable heterocycles present frequently in natural products drug candidates and bioactive molecules 1. Morales-Ríos 2 P. Phthalazino12-bquinazolinones as p53 Activators. Revised 12 January 2001.
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Camacho ME1 Chayah M1 García ME1 Fernández-Sáez N1 Arias F1 Gallo MA1 Carrión MD1. Synthetic Study and Biological Evaluation. This review illustrates the scope of C-H activation and functionalization of various. Beatty and Bradley D. TETRAHEDRON LETTERS Pergamon Tetrahedron Letters 42 2001 18511854 One-step synthesis of 43H-quinazolinones Martin J. Joseph-Nathan 2 Monatshefte für Chemie Chemical Monthly volume 126 pages 789794 1995Cite this article.
Information and translations of quinazolinones in the most comprehensive dictionary definitions resource on the web.
Studies have found that air as well as water plays an important role in synthesis of quinazolinones. Quinazolinones therapeutic use Receptors AMPA antagonists inhibitors Receptors N-Methyl-D-Aspartate antagonists inhibitors Tinnitus drug therapy Substances AUT00063 Apoptosis Regulatory Proteins Imidazoles. Quinazolinones have strongly attracted the interest of medicinal chemist as they constitute a large class of compounds that exhibited broad spectrum of biological activities including antimicrobial antimalarial anticonvulsant anticancer antileishmanial. Camacho ME1 Chayah M1 García ME1 Fernández-Sáez N1 Arias F1 Gallo MA1 Carrión MD1. Kernresonanzspektroskopie von 43H-Chinazolinonen und 43H-Chinazolinthionen. Phthalazino12-bquinazolinones as p53 Activators.
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8 In the recent past quinazolinones were reported to exhibit pronounced coronary vasodilatory 9 and histamine receptor type 3 inverse agonism. 8 In the recent past quinazolinones were reported to exhibit pronounced coronary vasodilatory 9 and histamine receptor type 3 inverse agonism. Further investigation indicated that dihydroquinazolinones can be prepared with this protocol under the protection of N2. Quinazolinones are heterocyclic compounds with a wide range of medical applications such as antimicrobial antiviral antituberculosis and as enzyme inhibitors reviewed in 17 20 24. Quinazolinones are an important class of nitrogen-containing heterocycles which are widely found in numerous natural products and synthetic drugs.
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Quinazolinones therapeutic use Receptors AMPA antagonists inhibitors Receptors N-Methyl-D-Aspartate antagonists inhibitors Tinnitus drug therapy Substances AUT00063 Apoptosis Regulatory Proteins Imidazoles. Epub 2017 Aug 15. This structural framework isofbiomedicalimportanceasexemplifiedbythe anticancer drug idelalisibQuinazolinone formation by AsqJ follows an enzymatic pathway that diverges from the known AsqJ mechanism by redirecting the initial hydrogen abstrac-tion by the iron-oxo intermediateWenow report on the. Their ease of synthetic accessibility and flexibility in structural modifications and functionalization further adds to their appeal in medicinal chemi. Combination of MS and NMR methods identified the novel quinazolinones A 1 and B 2 which further expands the chemical space of this rich family of natural products.
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