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Ran Gtp Nuclear Transport. This concentration gradient underpins the major function of Ran the regulation of nucleocytoplasmic transport of RNA and proteins through the nuclear pore complex 2. Transport factors in the karyopherin-beta also called importin-beta family mediate the movement of macromolecules in nuclear-cytoplasmic transport pathways. Ran-GDP has been shown to shuttle from the cytoplasm to the nucleus where Ran becomes GTP-bound and active. In nuclear import for example the addition of GTP-Ran but not GDP-Ran has been shown to disassemble the karyopherin αβ complex and to release the β subunit from a repeat-containing nucleoporin.
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RanBP1 is required for nuclear transport but its. In nuclear import for example the addition of GTP-Ran but not GDP-Ran has been shown to disassemble the karyopherin αβ complex and to release the β subunit from a repeat-containing nucleoporin. The protein Ran is a small GTP-binding protein that binds to two types of effector inside the cell. Ran and Nuclear Transport. Karyopherin-beta2 transportin binds a cognate import substrate and targets it to the nuclear pore complex. Nuclear export works similar to nuclear import but in reverse and proteins contain a nuclear-export signal NES.
The Ras-related GTPase Ran functions in nucleocytoplasmic transport by regulating interactions of transport receptors with transport cargo.
Background Ran is a member of the Ras superfamily of small GTPases and has multiple roles in coordinating essential nuclear and mitotic processes in eukaryotes 1. Ran is an abundant GTP-binding protein that is required for the trafficking of proteins and RNA in and out of the nucleus Moore and Blobel 1993In general it forms a complex with nuclear transport signal NLS receptors and their cargoes and directs their movement through nuclear pores. The Ran-binding domain is a conserved sequence motif found in several proteins that participate in these transport. Ran is a small GTPase that has been implicated in a variety of nuclear processes including the maintainance of nuclear structure protein import mRNA processing and export and cell cycle regulation. Nuclear export works similar to nuclear import but in reverse and proteins contain a nuclear-export signal NES. One key function of Ran in nuclear transport may well lie in its ability to trigger the assembly and disassembly of transport complexes.
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Ran is an abundant GTP-binding protein that is required for the trafficking of proteins and RNA in and out of the nucleus Moore and Blobel 1993In general it forms a complex with nuclear transport signal NLS receptors and their cargoes and directs their movement through nuclear pores. M Dasso and R T Pu Laboratory of Molecular Embryology National Institute of Child Health and Human Development National Institutes of Health Bethesda MD 20892-5431 USA. Ran is an abundant GTP-binding protein that is required for the trafficking of proteins and RNA in and out of the nucleus Moore and Blobel 1993In general it forms a complex with nuclear transport signal NLS receptors and their cargoes and directs their movement through nuclear pores. Additionally Ran also regulates other cellular processes including cell cycle progression DNA replication RNA processing and mitotic spindle assembly. RanGTP activity drives import and export of RNA and proteins through the nuclear pore complex.
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Ran is an abundant GTP-binding protein that is required for the trafficking of proteins and RNA in and out of the nucleus Moore and Blobel 1993In general it forms a complex with nuclear transport signal NLS receptors and their cargoes and directs their movement through nuclear pores. Ran functions in the regulation nuclear protein import and export. Nuclear Import and Export RAN GTPaseThe Ran Ran-related or Ras-like nuclear protein is the single member of the Ran subfamily and the most abundant smal. Ran-GDP has been shown to shuttle from the cytoplasm to the nucleus where Ran becomes GTP-bound and active. Ran-binding proteins which have a role in terminating export processes from the nucleus to the cytoplasm and importin-beta-like molecules that bind cargo proteins during nuclear transport.
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Role of the Ran protein in nuclear import. Transport through the nuclear pore complex is driven by a gradient of RanGTP with a high concentration of RanGDP in the cytoplasm and a high concentration of RanGTP in the nucleusComplexes form between target proteins containing nuclear localization signals NLS importin-α and importin-β in the cytoplasm where Ran is in the GDP. In general it forms a complex with nuclear transport signal NLS receptors and their cargoes and directs their movement through nuclear pores. Role of the Ran protein in nuclear import. Nuclear Import and Export RAN GTPaseThe Ran Ran-related or Ras-like nuclear protein is the single member of the Ran subfamily and the most abundant smal.
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Karyopherin-beta2 transportin binds a cognate import substrate and targets it to the nuclear pore complex. As well as Kap-βs RanGTP also binds ranBP1 refs 28 33 37 and functionally similar RBH domains such as RBD1 in Nup358 refs 28 29. Ran is a small GTPase that has been implicated in a variety of nuclear processes including the maintainance of nuclear structure protein import mRNA processing and export and cell cycle regulation. Ran-binding proteins which have a role in terminating export processes from the nucleus to the. RanBP1 is required for nuclear transport but its.
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RanBP1 is required for nuclear transport but its. The protein Ran is a small GTP-binding protein that binds to two types of effector inside the cell. Transport through the nuclear pore complex is driven by a gradient of RanGTP with a high concentration of RanGDP in the cytoplasm and a high concentration of RanGTP in the nucleusComplexes form between target proteins containing nuclear localization signals NLS importin-α and importin-β in the cytoplasm where Ran is in the GDP. Karyopherin-beta2 transportin binds a cognate import substrate and targets it to the nuclear pore complex. There has been significant progress in determining the role of Ran in nuclear protein import.
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