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Succination. We undertook a proteomic-based screen in cells. Succinylation mediates mitochondrial translocation of PKM2. We report the identification of a novel succinated protein dihydrolipoyllysine-residue succinyltransferase DLST a component of the α-ketoglutarate dehydrogenase complex KGDHC of. Succination is a non-enzymatic PTM of cysteine by the Krebs cycle metabolite fumarate leading to the generation of 2SC which is considered a biomarker of mitochondrial stress.
Ectopic Expression Of The Tere1 Ubiad1 Protein Inhibits Growth Of Renal Clear Cell Carcinoma Cells Altered Metabo Reactive Oxygen Species Nitric Oxide Renal From pinterest.com
Succination plural succinations organic chemistry Reaction with a derivative of succinic acid biochemistry Post-translational modification of protein that occurs when fumarate reacts with cysteine groups. How to use succinct in a sentence. In mice the administration of DMF protects against lipopolysaccharide shock and alleviates familial Mediterranean fever and experimental autoimmune encephalitis by targeting GSDMD. In eukaryotes this reactivity results in succination of glutathione GSH. 2SC was detected in human serum albumin and skin collagen and was increased in skeletal muscle protein and urine of diabetic rats. We report the identification of a novel succinated protein dihydrolipoyllysine-residue succinyltransferase DLST a component of the α-ketoglutarate dehydrogenase complex KGDHC of.
This review describes succination of proteins an irreversible chemical modification of cysteine by the Krebs cycle intermediate fumarate yielding S-2-succinylcysteine 2SC.
Succinylation mediates mitochondrial translocation of PKM2. A Succinct History of succinct Synonym Discussion of succinct. To gain insight into the mitochondrial translocation of PKM2 induced by glucose. In eukaryotes this reactivity results in succination of glutathione GSH. Succination is a chemical modification of cysteine in. In mice the administration of DMF protects against lipopolysaccharide shock and alleviates familial Mediterranean fever and experimental autoimmune encephalitis by targeting GSDMD.
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This reaction in which a thioether bond is formed is described as succination of protein in order to distinguish it from succinylation which leads to formation of amide ester or thioester bonds. To gain insight into the mitochondrial translocation of PKM2 induced by glucose. This modification is found in many proteins including histones. 2SC was detected in human serum albumin and skin collagen and was increased in skeletal muscle protein and urine of diabetic rats. In mice the administration of DMF protects against lipopolysaccharide shock and alleviates familial Mediterranean fever and experimental autoimmune encephalitis by targeting GSDMD.
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