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T790m Test. Tumor enrichment is performed before extraction. This test evaluates cell-free DNA cfDNA in the peripheral blood for the presence of the EGFR T790M mutation in patients with non-small cell lung cancer NSCLC and can be used to assess eligibility for targeted therapies. This test detects only the T790M mutation in the EGFR gene. This test is not a prenatal screening test.
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Besides tissue-based testing blood samples containing cell-free circulating tumor DNA ctDNA can be used to interrogate T790M status. Detect quantify and monitor EGFR T790M mutations in blood with unparalleled sensitivity. Bi-directional sequencing of exons 18-21 of the EGFR gene for detection of EGFR-activating mutations and TKI resistance mutations including T790M in these exons. Merinda V1 Soegiarto G2 Wulandari L3. This test evaluates cell-free DNA cfDNA in the peripheral blood for the presence of the EGFR T790M mutation in patients with non-small cell lung cancer NSCLC and can be used to assess eligibility for targeted therapies. By Alyssa Frank January 31 2018.
The T790M mutation is an important predictive biomarker in NSCLC and its identification has considerable clinical relevance.
Merinda V1 Soegiarto G2 Wulandari L3. The cobas EGFR Mutation Test v2 has been clinically validated in multiple clinical trials as a companion. T790M also known as Thr790Met is a gatekeeper mutation of the epidermal growth factor receptor EGFR. The results demonstrate the utility of liquid biopsy for the detection of T790M with the Cobas EGFR Mutation Test v2. It does not detect other EGFR gene mutations in. For tissue testing order EGFRT EGFR Gene Mutation Analysis 29 Mutation Panel Tumor.
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This test provides rapid detection of the EGFR T790M mutation in peripheral blood from non-small cell lung cancer patients as an alternative for EGFR analysis of tissue. This test is not a prenatal screening test. For tissue testing order EGFRT EGFR Gene Mutation Analysis 29 Mutation Panel Tumor. Detect quantify and monitor EGFR T790M mutations in blood with unparalleled sensitivity. A T790M-positive result occurred in 239 of patients at first rebiopsy Table 4.
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